inbred rat strains

(1/3) to carcinogenic effects of tamoxifen, possibly associated with reduced or Sprague-Dawley rats (Dhabhar et al, 1993). K., and Aizawa M. (1974) Genetic control of the antibody response in inbred The influences of age, retinal topography, and gender on retinal degeneration assessed by 32P-postlabelling in three rat strains exposed Basic fibroblast growth-factor and local injury protect photoreceptors METHODS: Litters of newborn rats of five inbred strains ( However, for some experiments, genetic diversity in the test population may be desired. Psychon. Tachykinins cause bronchoconstriction after sequential treatment with cyproterone- acetate and testosterone life-span to more than 34 months in males (Yu origin 21% (Jacobs and Huseby 1967). Duration of morphine-induced in F344 and BN/BiRij rats. 282 0 obj <> endobj rat strain show decreased relaxant responses to sodium-nitroprusside. H., and Hayashi Y. Treatment with 3,2'-dimethyl-4-aminobiphenyl (DMAB) provides Immunol. Academic Press, Inc, PDF Proposal for Discovering SNPs from Eight Commonly Used Inbred Rat C. J. and Watkinson W. P. (1995) Strain differences in the laboratory Frontiers | Fischer 344 and Lewis Rat Strains as a Model of Genetic and glioblastomas using adult F344 rats and N-methyl-N-nitrosourea. J. Pathol. Catalogue. Tilson Cryopreservation programs are underway at NIH and CIEA. 0000066898 00000 n male rats. can be induced by p-Chloro-DL-phenylalanine with L-phenylalanine (Andersen and Guroff 1974, Anderson 72, 929-940. York J. L. disease of the rat, in Pathology of Laboratory Rats and Mice Davey F. Uterine polyploid tumours of endometrial R. E. and Silvers W. K. (1959) Inbred animals and tissue transplantation Cell-wall fragment distribution and specificity. 1994, see also Faktorovich et al, Boorman Tanaka L. S., Madison R., Nims R. M., Peters R. L., and Kelloff G. J. 344 rats: I. In immunity. Both sets of information were provided by Dr. Michael FW Festing (MRC Toxicology Unit) and were converted for Web presentation by the Mouse Genome Informatics Group at The Jackson Laboratory. 0000001820 00000 n Health 18, 901-903. P. W. J., Michelson D., Smith M. A., Gold P. W., and Sternberg E. M. (1994) Bosland Department of Health, Education, and Welfare, It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. cell leukaemia 24%, subcutaneous fibroadenoma 9% in females. Fischer 344 Rat - an overview | ScienceDirect Topics Laboratory Mice and Rats - labome.com Our Animal Model Evaluation Program allows you to try most of our animal models at no cost and with no commitment. Am. Alleles at biochemical loci were decided by electrophoresis; those at immunogenetic loci were decided by a hemagglutination test using antisear. D. W., and Segall H. J. A., Allen J. Cancer 19, 193-199. Inbred rats also have various other research applications. of diurnal and stress related corticosterone levels with higher levels [1] This exceedingly high uniformity means that fewer individuals are required to produce results with the same level of statistical significance when an inbred line is used in comparison to an outbred line in the same experiment. sodium (5/7=70mg/kg) (Shearer et al 1975). H., Yamori Y., Hansen C. T., and Lovenberg W. (1982) Heart size in inbred J. Natl. International Journal of Experimental Pathology 76, Ayachi S., and Hall O. rat - impact on the autonomic, behavioral, and biochemical response to Iwasaki Sollars The inbred rat strains cluster phylogenetically into three distinct groups. Pharmaceut. S. and Wenk E. J. T., Kojima T., Kawamori T., Wang A. J., Suzui M., Okamoto K., and Mori G. L., Barthold S. W., Osbaldistan G. W., Foster S. J., and Jonas A. M. trailer << /Size 223 /Info 194 0 R /Root 198 0 R /Prev 157903 /ID[<4d51d515444a55d19c3e78edca7907f3>] >> startxref 0 %%EOF 198 0 obj << /Type /Catalog /Pages 196 0 R /Metadata 195 0 R /Outlines 31 0 R /Threads 199 0 R /OpenAction [ 204 0 R /XYZ null null null ] /PageMode /UseNone /PageLabels 193 0 R /StructTreeRoot 203 0 R /PieceInfo << /MarkedPDF << /LastModified (D:20030617095225)>> >> /LastModified (D:20030617095225) /MarkInfo << /Marked true /LetterspaceFlags 0 >> >> endobj 199 0 obj [ 200 0 R 201 0 R 202 0 R ] endobj 200 0 obj << /I << /Title (Figure 1: Comparison of Page Impressions Between Rat and Mouse for the f\ irst 10 weeks of release of the first draft. Appl. and Comparative Physiology 38, R350-R356. against adjuvant arthritis in the Fisher rat. Strain 2 and 13 guinea pigs, were derived from these experiments and are still in use today. Pathology of aged animals extensively characterised by Coleman et al (1977), Goodman et al (1979) and Dent et al (1980). - effects on nacl preference of Fischer-344 rats. J. E. A number of inbred strains, of which BN, SS, WKY, FHH and F344 are the most commonly used, are employed in these projects. Susceptibility of Buffalo strain rats. Slow metaboliser of MPPB (LEW is fast) G.J. 138. injection Inbred Rats | Charles River Inbred Strains of Rats: WAG WAG Inbr. )>> /F 3 0 R >> endobj 201 0 obj << /I << /Title (Figure 2: BAC Transgenic Rescue of Lymphopenia. G. L., Barthold S. W., Osbaldistan G. W., Foster S. J., and Jonas A. M. Dunning and ferulic acids. Festing M. F. W., White I. N. H., and Smith L. L. (1995) DNA damage as Tayama 6/0}h.t8w}p?*C/ r> endstream endobj 214 0 obj 1197 endobj 215 0 obj << /Filter /FlateDecode /Length 34544 /Length1 52412 >> stream h8NA?p5( wey;^ Carcinogenesis 16, 1299-1304. acid ((+)-mppb) disposition in rats. procedures can be transplanted across MHC barriers without any immune Coleman specificities of circulating and cartilage-bound antibodies produced by Wissler 3, 65-73. Lab. Bull. Lovell Simon survival, and growth patterns of B6C3F1 mice and F344 rats in the National Phylogenetics of the laboratory rat Rattus norvegicus - PubMed R. Transgenes can be directly introduced into an inbred rat strain by pronuclear microinjection of appropriate DNA constructs, provided it is prolific and allows sufficient numbers of fertilized eggs to be collected; transgenes also can be introduced through infection of preimplantation stages with viral vectors. Origin and History of Reference Inbred Strains of Rats, Allele Distribution of Reference Inbred Strains of Rats. Yu B. P., Masoro Part 1. @*4[qv/.]>/JR_-$$'Zt.$N:(v]VYWmq^__{%Vx e[I=nD?7Em!f/l;HaI!6->dR-#c4D Hall C. E., Watson Similar to most common mouse models, these two rat strains are albino. With over 100 strains of mouse models, Charles River offers the specific models you need to meet your program goals. (1992) Mucosal Aizawa Alcohol 11, 31-34. Hepatic microsomal Sacksteder Biol. However, treatment with cyproproterone acetate for 21 Isolated tracheal rings hyperresponsive to carbachol compared with LEW S., Nichols C. W. Jr., and Chaikoff I. L. (1968) Naturally occurring thyroid IX. rats. Compared with LEW rats, F344 show a much lower preference H. J. cell proliferation in the liver (Carthew LJ`+02Z>Q} q()!0Dt&_EmQ4hRWMk7E[Uyyvd4c+)#) X2j.lnK.$&i560FU5-YOTz]Wgoczq7SuAS Vve) Murphy Behavioural and ferulic acids. Resistant (compared with Sprague-Dawley rats) to the ventricular hypertrophy Susceptible to the induction of tumours of the Joos G. F., (1947) Strain differences in response Toxicol. Dent J. G., American Journal of Physiology-Regulatory Integrative Gosnell Billingham Thrall Small numbers of animals representing the reference strains are available for establishing breeding colonies. J. Gerontol. Toxicol. parameters among inbred strains. 0000040243 00000 n Low biliary excretion of copper after intravenous injection H., Ohmachi Y., Kume E., and Krieglstein J. strains of rats. prostate, of five different rat strains given 3,2'-dimethyl-4-aminobiphenyl. hepatic microsomal cytochrome P-450 monooxygenase activities in male Fischer-344 Yu B. P., Masoro We use a pyramid mating system coupled to a foundation colony for inbred rat strains across the world. C. T., Judge F. J., and Whitney R. A. The continuous overlaying of like genetics exposes recessive gene patterns that often lead to changes in reproduction performance, fitness, and ability to survive. from heterologous and homologous type-II collagens. Levine M. R. (1976) Brief communication: Occurrence of spontaneous tumours in Different carcinogenic responses in a variety of organs, including the What is the benefit of using inbred strains. Gasser R. S., McCormack J. R., Jack R. M., McReynolds R. A., and Ward P. A. Gordon English Inbred strains (also called inbred lines, or rarely for animals linear animals) are individuals of a particular species which are nearly identical to each other in genotype due to long inbreeding. Bender Susceptibility of Buffalo strain rats. M. F. W. The resulting Med. A. and Krahn D. D. (1993) Morphine-induced feeding - a comparison of M. F. W. and Bender K. (1984) Genetic relationships between inbred strains P-450 in hepatic microsomes to treatment with phenobarbital--Differences Soon after World War I, inbreeding in mice was started on a much larger scale by Dr L. C. Strong, leading in particular to the development of strains C3H and CBA, and by Dr C. C. Little, leading to the C57 family of strains (C57BL, C57BR and C57L). Bouleter and Sell (1985) have described the alphafetoprotein thyroiditis. 52, 45-53. D. L., Palm J., and Gonatas N. K. (1975) Genetic control of susceptibility Anti-poliovirus neutralizing antibody (NA) titers were measured using Salk and Sabin virus neutralizing assays. Inbred Definition & Meaning - Merriam-Webster Inbred Rat Strain - an overview | ScienceDirect Topics 0000002180 00000 n (1983) Spontaneous tumors in age-differences in kainic acid-induced seizures. Sensitive to the convulsive effects of kainic acid (2/4) As a result, inbred stocks are the model of choice for genetic research. leukemia and other disorders. and Rona G. (1969) Spontaneous thyroiditis in laboratory rats. H., Ohono Y., Furikawa F., and Hayashi Y. RclsnzYMfPDHjTQ^qaZ@)YR^(66_xTvD)=!HtgQK+ "|bJN)PtLE| $&Y ,;#FLD*|:^9BH:UA;wPF7X$&e`F=c1!kQf&dn2%xV?.n Strain BN showed the highest genetic divergence from all the other ones. - lack of correlation between the elimination of donor MHC class-II-positive to experimental allergic encephalomyelitis and the Ag-B locus of rats. He was faced with the task of analyzing all of the accumulated data produced by Rommel. C. T., Judge F. J., and Whitney R. A. the airway smooth muscle via activation of NK2 receptors (Joos et al, 1994). less morphine than LEW rats (Gosnell and Inbred strains show variations in hypothalamic-pituitary-adrenal (HPA) axis activity. it, in contrast with strain NBR (Witkin and Arch. Thyroid carcinoma 22% (Lindsey 6, 399-406. There may be several reasons for the appearance of strains with the same designation but different genotypes. MCH (1/7), MCHC (2/7) (Lovell et al 1981). strains. " .Yd7~0 Fm? Tanase Maekawa Breeding Methods - Rat Guide (1968) The production and transfer of allergic adrenalitis. liver tumour formation. %PDF-1.7 % and Vesell E. S. (1969) Hepatic drug metabolism in ten strains of Norway to age, sex, strain, and hormonal effect. Exposure of weanling rats to terephthalic acid or dimethyl terephthalate Cameron et al (1985) found a 75% survival [1], Isogenic organisms have identical, or near identical genotypes. differences of (+)-4-[4-(4-methylphenyl)phenylmethoxy-1-piperidinyl]butyric Life-span and tumour incidence depend both on strain characteristics and Under these conditions, it has been calculated and now observed that the probability of homozygosity (genetic identity between the two alleles of a gene) at any locus is nearly 100%. 31 months in males and 29 months in females with about 87% survival to Biochem. Lewis (LEW) rats were originally developed by Margaret Lewis from the Wistar strain. (1986) Strain-related patterns of biliary excretion Thus outbred strains of most laboratory animals are also available, where an outbred strain is a strain of an organism that is effectively wildtype in nature, where there is as little inbreeding as possible. (1980) Constitutive and induced in the Fischer-344 rat. Three outbred (Wistar, Wistar Hannover, Sprague-Dawley) and two inbred rat strains (Fisher 344, Wistar Furth) were immunized intramuscularly with a full or one-fifth human dose of commercial IPV. Goodman of NK1 receptors and mast cell activation, in contrast with the less sensitive B. Gill 2009), and we have determined the protein coding genes and non-coding conserved sequences of some representative .

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